As cities face the challenge of conceiving new and more competitive and sustainable development models, there has been an emergence of introducing technology to cities to enhance the quality of life it provides to the citizens. The 'Smart City' was proposed as a new prototype of technology-based urban development. These smart cities witness the emergence of the metaverse and platform societies, machine learning and artificial intelligence (ML/AI), big data, the Internet of Things (IoT) systems, and many other innovative and advanced technologies. However, the idea of the Smart City has

Purpose: Residing in a densely populated urban area possesses its allure; nonetheless, it can significantly impact physical and mental well-being owing to the persistent stress and information overload inherent in urban settings. This study aims to introduce a neuro-urbanism framework that can guide urban planners and designers in quantitatively evaluating individuals' responses to virtual simulated environments. Design/methodology/approach: Our study consisted of two phases after randomly selecting six locations representing three types of urban areas in Bratislava, Slovakia: urban spaces

The urban scenery that dominated Cairo since the nineteenth century was a spatial superimposition of tradition and modernity, represented in the social and architectural composition of the city. The cinematic medium in Egypt attempted to visualize such overlap through a vivid depiction of spatial transformations occur-ring within the micro and macro urban levels revealing hidden aspects of social order and organizational behaviour. This article sheds light on Egyptian filmmaker Hassan Al-Imam’s Cairo Trilogy films, based on the critically acclaimed novels by Nobel Prize laureate Naguib Mahfouz

Purpose: Few public places are designed with due consideration to the needs and preferences of teens. Teens in public spaces are often viewed with apprehension from other user groups. Teens hanging out in public spaces are always observed with caution and are sometimes associated with negative behaviour by other community members. In designing public spaces that are suitable for the teens and not alienating them to other members of the community, it is necessary to understand how teens perceive their environment and what they expect from it. The psychological, social and emotional development

[No abstract available]

Antimicrobial resistance (AMR) is one of the threats to our world according to the World Health Organization (WHO). Resistance is an evolutionary dynamic process where host-associated microbes have to adapt to their stressful environments. AMR could be classified according to the mechanism of resistance or the biome where resistance takes place. Antibiotics are one of the stresses that lead to resistance through antibiotic resistance genes (ARGs). The resistome could be defined as the collection of all ARGs in an organism’s genome or metagenome. Currently, there is a growing body of evidence

Non-Structural Protein 6 (NSP6) has a protecting role for SARS-CoV-2 replication by inhibiting the expansion of autophagosomes inside the cell. NSP6 is involved in the endoplasmic reticulum stress response by binding to Sigma receptor 1 (SR1). Nevertheless, NSP6 crystal structure is not solved yet. Therefore, NSP6 is considered a challenging target in Structure-Based Drug Discovery. Herein, we utilized the high quality NSP6 model built by AlphaFold in our study. Targeting a putative NSP6 binding site is believed to inhibit the SR1-NSP6 protein-protein interactions. Three databases were

Type 2 diabetes mellitus (T2D) remains a critical health concern, particularly in its early disease stages such as prediabetes. Understanding these early stages is paramount for improving patient outcomes. Multiomics data integration tools offer promise in unraveling the underlying mechanisms of T2D. The advent of high-throughput technology and the increasing availability of multiomics data has led to the development of several statistical and network-based integration methods. However, the performance of such methods varies, requiring their output evaluation in an unbiased manner. Here, we

The need for a comprehensive consolidated guide for R packages and tools that are used in microbiome data analysis is significant; thus, we aim to provide a detailed step-by-step dissection of the most used R packages and tools in the field of microbiome data integration and analysis. The guideline aims to be a user-friendly simplification and tutorial on five main packages, namely phyloseq, MegaR, DADA2, Metacoder, and microbiomeExplorer due to their high efficiency and benefit in microbiome data analysis. © 2023, The Author(s), under exclusive license to Springer Science+Business Media, LLC

Biomedical research and pharmaceutical development have been profoundly impacted by genomics in recent years, with researchers gaining new understanding of the genetic pathways underlying disease and opening up new opportunities for the creation of targeted therapeutic interventions. Without a comprehensive grasp of the genetic mechanisms at play, medication discovery approaches in the past often relied on trial and error, targeting particular symptoms or pathways. However, the advent of genomics has changed the game. Scientific advances in high-throughput DNA sequencing have allowed