The need for a comprehensive consolidated guide for R packages and tools that are used in microbiome data analysis is significant; thus, we aim to provide a detailed step-by-step dissection of the most used R packages and tools in the field of microbiome data integration and analysis. The guideline aims to be a user-friendly simplification and tutorial on five main packages, namely phyloseq, MegaR, DADA2, Metacoder, and microbiomeExplorer due to their high efficiency and benefit in microbiome data analysis. © 2023, The Author(s), under exclusive license to Springer Science+Business Media, LLC

Biomedical research and pharmaceutical development have been profoundly impacted by genomics in recent years, with researchers gaining new understanding of the genetic pathways underlying disease and opening up new opportunities for the creation of targeted therapeutic interventions. Without a comprehensive grasp of the genetic mechanisms at play, medication discovery approaches in the past often relied on trial and error, targeting particular symptoms or pathways. However, the advent of genomics has changed the game. Scientific advances in high-throughput DNA sequencing have allowed

Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Chronic hepatitis and liver cirrhosis lead to accumulation of genetic alterations driving HCC pathogenesis. This study is designed to explore genomic landscape of HCC in Egyptian patients by whole exome sequencing. Methods: Whole exome sequencing using Ion Torrent was done on 13 HCC patients, who underwent surgical intervention (7 patients underwent living donor liver transplantation (LDLT) and 6 patients had surgical resection}. Results: Mutational signature was mostly S1, S5, S6, and S12 in HCC. Analysis of

Tables 2, 3, and 6, as shown in the original publication, were modified to black and white during the typesetting process. Following the publication, the authors requested that the tables be reverted to their original-colored versions, as the colors in the heatmap indicate the number of pathogenic variants present in genes. Green indicates the smallest number, and red indicates the highest number. The colored tables are as follows: Heatmap for pathogenic variants in highly mutated genes in HCC samples Heatmap for pathogenic variants in highly mutated genes in Non-HCC samples Heatmap showing

Purpose: Petroleum companies have various goals in light of high energy prices, uncertainty and potential fluctuations in demand in the current digital age, including making a profit while maintaining long-term sustainability and lowering their environmental impacts. The purpose of this paper is to explore the impact of technology management (TM) and its practices through process and maintenance technologies on sustainability performance (SP) for petroleum refineries and petrochemical companies in terms of economic, environmental and social sustainability. Design/methodology/approach: A new

The Presales process takes place before closing the deal between a company and a customer. Presales teams engage with customers to understand their needs and support them in purchasing decisions. Presales employees need to combine both technical and business skills as they communicate with multiple entities, such as customers, sales, technical teams, and others. A well-defined Presales process helps companies acquire more customers. Therefore, this study aims to explore the Presales process by defining the main activities, stakeholders, and the needed skills to develop a competent Presales

High-technology companies usually hire presales teams to help customers make purchase decisions. The presales team communicates with customers and proposes solutions meeting their needs. Accordingly, the presales team needs to develop the required technology and business knowledge to conduct the presales activities successfully. Presales teams with proper knowledge management can respond efficiently to customers. This paper aims to design a Knowledge Management Framework for presales activities. To collect data, a literature review in addition to interviewing multiple presales employees was

Future always starts now; we simply do not know that! COVID-19 has triggered a new phase of human evolution! It disrupted every aspect of our life. It created new norms for everything, from education to supply chains to employment to healthcare to economy to personal hygiene! We are still in the middle of the pandemic, and the impact on both economic and social levels is not clear yet, and its severity would depend on how long the pandemic would endure. Based on that the paper outlines the disruptions prior to the virus outbreak and acted as a double-edged sword, such as the infodemic

Everything is going digital around us! Disruptive technologies and their disruptive use models are creating a new world and a different future. Over the last few years, the creation and utilization of technologies has played a critical role to improve the life quality of people, advance economies, and open new horizons for individuals, businesses, and even nations around the world. This is the bright side! On the other side, the world is experiencing nowadays exceptional technology disruption that has triggered an enormous change; a change that is behind the classical control of the

Smart Cities are viewed by a few as a show, by others as a trend, but by many as a necessity. To cope with the growing pressures of urbanization and the complications of citizens’ urban needs, an integrated hi-tech solution is needed. After all, many renowned cities around the world are adopting it: London, Dubai, Cape Town and many others. Is there a set-menu to adopt for a smart city approach? Should urbanists seek set standards for quality assurance or develop localized approaches? This research is the findings of an 18-month-long in-depth analysis using extensive case studies and detailed