In this work, we investigate the effect of using spatio-tepmoral features on a regional basis on the liver focal lesions classification performance in the multiphase CT images. Texture, Density, and temporal feature set and their different combinations along spatial partitioned ROI were investigated to better characterizing five hepatic pathologies from multiphase contrast-enhanced CT scans. Embedded feature selection followed by decision tree ensembles classification with ten folds cross-validation were employed to classify a total of 180 ROI includes normal tissues, cyst, haemangioma

Heart segmentation in Cardiac MRI images is a fundamental step to quantify myocardium global function. In this paper, we introduce a pipeline for heart localization and segmentation that is fast and robust even in the apical slices that have small myocardium. Also, we propose an enhancement to the popular U-Net architecture for segmentation. The proposed method utilizes the aggregation of different feature scales from the image by using the inception block along with the multi-gate block that propagates the multi-scale context of the supplied data where the heart is subject to changes in scale

The introduction of next generation sequencing technologies did not bring only huge amounts of biological data but also highly sophisticated and versatile analysis workflows and systems. These new challenges require reliable and fast deployment methods over high performance servers in the local infrastructure or in the cloud. The use of virtualization technology has provided an efficient solution to overcome the complexity of deployment procedures and to provide a safe personalized execution box. However, the performance of applications running in virtual machines is worse than that of those

Codon optimization is primarily used in enhancing the levels of protein expression in the host species. Each species has its own codon usage bias, which represents the codons abundance frequency in that species. Using the host usage profile contributes to personalize the synthesis of the DNA vaccines that can achieve highly active vectors the host cells. For optimizing protein expression levels in a particular host, the genetic code sequence needs correction of codon frequency bias to match the expression of host codon landscape rather than the donating organism profile. In this work, we have

Traditional mobile application development requires going through multiple development cycles in order for an application to work on different platforms. In cross-platform development, the application goes through only one development cycle to be deployed in multiple environments. Various cross-platform methodologies were explored to make it easy for developers to deploy their apps; one of which is the Trans-Compiler methodology. This paper discusses advances to a cross-platform solution, TCAIOSC, which converts Android projects to iOS, inquiring into further aspects of Android-To-iOS

Background: Next Generation Genome sequencing techniques became affordable for massive sequencing efforts devoted to clinical characterization of human diseases. However, the cost of providing cloud-based data analysis of the mounting datasets remains a concerning bottleneck for providing cost-effective clinical services. To address this computational problem, it is important to optimize the variant analysis workflow and the used analysis tools to reduce the overall computational processing time, and concomitantly reduce the processing cost. Furthermore, it is important to capitalize on the

Personal health record service avail patients to store and dominate their healthy information data through the cloud. Many users like medical doctors, health care providers and family members can access this data through the internet. However, there are privacy issues related to data exposure and data breaches, causing risk to patients' lives. Encryption techniques like public key encryption are applied but they are not efficient and very complex, in addition to scalability problems. In this paper, various multi-authority attributes based on encryption solutions features are discussed that

Despite the important role of object tracking using the Optical Flow (OF) in computer graphics applications, it has a limited role in segmenting speckle-free medical images such as magnetic resonance images of the heart. In this work, we propose a novel solution of the OF equation that allows incorporating additional constraints of the shape of the segmented object. We formulate a cost function that include the OF constraint in addition to myocardial contour properties such as smoothness and elasticity. The method is totally different from the common naïve combination of OF estimation within

Evaluation of cardiac functions using Strain Encoded (SENC) magnetic resonance (MR) imaging is a powerful tool for imaging the deformation of left and right ventricles. However, automated analysis of SENC images is hindered due to the low signal-to-noise ratio SENC images. In this work, the authors propose a method to segment the left and right ventricles myocardium simultaneously in SENC-MR short-axis images. In addition, myocardium seed points are automatically selected using skeletonisation algorithm and used as hard constraints for the graph-cut optimization algorithm. The method is based

RNA interference (RNAi) is a post-transcriptional gene silencing mechanism that mediates the sequence-specific degradation of targeted RNA and thus provides a tremendous opportunity for development of oligonucleotide-based drugs. Here, we report on the design and validation of small interfering RNAs (siRNAs) targeting highly conserved regions of the hepatitis C virus (HCV) genome. To aim for therapeutic applications by optimizing the RNAi efficacy and reducing potential side effects, we considered different factors such as target RNA variations, thermodynamics and accessibility of the siRNA