Cole-Cole Bio-Impedance Parameters Extraction from a Single Time-Domain Measurement

We show that the four parameters of a single-dispersion Cole-Cole bio-impedance model can be extracted from an one time-domain measurement with a fixed frequency. In particular, a periodic triangle waveform current excitation signal is injected into the biological sample under study while measuring the voltage developed across this sample in a galvanostatic measurement setup. The voltage response due to this triangle-wave excitation is firstly analytically derived in closed form. After that the Flower Pollination optimization Algorithm (FPA) is applied to extract the unknown model parameters that best fit the measured voltage response to the derived analytical expression. Experimental results using apple samples show excellent agreement between theory and measurements. © 2019 IEEE.