OMICS and bioinformatics in Parkinson disease and related movements disorders

This chapter explores the integration of omics and bioinformatics for Parkinson's disease (PD) diagnosis and potential cure discovery. It begins with an overview of PD and its prevalence, followed by an examination of key mutations in genes linked to the disease. These mutations lead to dysfunctional proteins, triggering PD progression. The chapter delves into techniques like whole-exome sequencing (WES), genome-wide association sequencing (GWAS), and whole-genome sequencing (WGS). These methods enable the exploration of omics levels such as lipidomics, metabolomics, genomics, and proteomics for PD diagnosis and pattern identification. Finally, it addresses challenges in integrating omics with PD and related movement disorders. © 2025 Elsevier Inc. All rights reserved.